An Optimization via Simulation approach for the preemptive and non-preemptive multi-mode resource-constrained project scheduling problems

In this paper a novel modelling and solving method has been developed to address the so-called resource constrained project scheduling problem (RCPSP) where project tasks have multiple modes and also the preemption of activities are allowed.To solve this NP-hard problem, a new general optimization via simulation (OvS) approach has been developed wh

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Bile effects on the Pseudomonas aeruginosa pathogenesis in cystic fibrosis patients with gastroesophageal reflux

Gastroesophageal reflux (GER) occurs in most cystic fibrosis (CF) patients and is the primary source of bile aspiration in the airway tract of CF individuals.Aspirated bile is associated with the severity of lung diseases and chronic inflammation caused by Pseudomonas aeruginosa as the most common pathogen of CF respiratory tract infections.P.aerug

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